Clinical pharmacology and therapeutics.

Toxicological assessment of ethanol seed extract of Citrus paradisi Macfad (grapefruit) on oxidative status, organ function and histoarchitecture in Wistar rats

Background & Aim:Citrus paradisi Macfad (Rutaceae) seed extract (CPE) is used in folkloric medicine for the management of diabetes, blood deficiencies and as immune booster, which may require long term usage. This study aimed to evaluate the toxicity profile of ethanol seed extract of grapefruit in adult Wistar rats in order to determine its safety profile in whole org...

Advancing pharmacometrics and systems pharmacology.

Pharmacometrics and systems pharmacology are emerging as principal quantitative sciences within drug development and experimental therapeutics. In recognition of the importance of pharmacometrics and systems pharmacology to the discipline of clinical pharmacology, the American Society for Clinical Pharmacology and Therapeutics (ASCPT), in collaboration with Nature Publishing Group and Clinical ...

Amodiaquine-Associated Asthenia: A Case Based Review and Gaps in Literature

Introduction: Amodiaquine is a partner drug in the artemisinin-based combination therapy artesunate-amodiaquine. Reports of the adverse drug reaction known as amodiaquine-associated asthenia are scarce, and this adverse reaction needs to be investigated in detail. This article presents and reviews a case of amodiaquine-associated asthenia. A literature search for the characteri...

Clinical Pharmacology & Therapeutics: Past, Present, and Future.

Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development, regulation, and utilization continuum to catalyze, evolve, and disseminate discipline-transformative knowledge. Prioritized themes and multidisciplinary content drive the science and practice of clinical pharmacology, offering a trusted poi...

Evaluation of Levels of Potassium Bromate and Some Heavy Metals in Bread and Wheat Flour Sold in Aba Metropolis

The economics of drug development: a grim reality and a role for clinical pharmacology.